Orexin induces excitation of respiratory neuronal network in isolated brainstem spinal cord of neonatal rat

Orexin induces excitation of respiratory neuronal network in isolated brainstem spinal cord of neonatal rat

Highlights • We analyze effects of orexin on central respiratory control using the isolated brainstem–spinal cord preparation of newborn rats. • Orexin produces dose-dependent increases in C4 burst rate via brainstem. • The increases in C4 respiratory activities are associated with orexin-induced de...

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Veröffentlicht in:Respiratory physiology & neurobiology 2014-08, Vol.200, p.105-109
Hauptverfasser: Sugita, Takeo, Sakuraba, Shigeki, Kaku, Yuki, Yoshida, Kazu-ichi, Arisaka, Hirofumi, Kuwana, Shun-ichi
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Animals, Newborn
Brain Stem - physiology
Central respiratory control
Electric Impedance
Intracellular Signaling Peptides and Proteins - metabolism
Medical Education
Membrane Potentials - physiology
Neonate
Neurons - physiology
Neuropeptides - metabolism
Orexin
Orexins
Patch-Clamp Techniques
Pulmonary/Respiratory
Rats
Respiration
Spinal Cord - physiology
Tissue Culture Techniques
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Zusammenfassung:Highlights • We analyze effects of orexin on central respiratory control using the isolated brainstem–spinal cord preparation of newborn rats. • Orexin produces dose-dependent increases in C4 burst rate via brainstem. • The increases in C4 respiratory activities are associated with orexin-induced depolarization of pre-inspiratory and inspiratory neurons.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2014.06.006