A Comparative Study of Early Bone Formation with PRF, Bio-Oss and Osteoid Hydroxyapatite after Tooth Extraction in Rabbits

The objective of this study was to compare the ability of platelet-rich fibrin (PRF), Bio-Oss and osteoid hydroxyapatite (OHA) in early bone formation by fillingtooth extraction socketsin rabbits. 48 rabbits were randomly divided into 4 groups: group A (PRF), group B (Bio-Oss), group C (OHA), and group D (control). One of the mandibular central incisors was extracted and instantly filled with graft materials. General, radiological and histological observations were evaluated 1, 2, 3, 4, 6, and 8 weeks later. In the first 4 weeks, the quantity of new bone in the PRF group alveolar defects was the best, and the bone mineral density was significantly higher. At the 6th and 8th weeks, the speed of new bone formation in the Bio-Oss group and the OHA group was better than that in the PRF group. Compared with the Bio-Oss group, the OHA group had osteoblasts which were more active and a slightly larger number of bone trabeculae. In addition, the control group was worse than other groups in bone-formation. These results indicate that PRF, OHA and Bio-Oss all can promote osteogenesis in tooth extraction sockets, but the effect of PRF is remarkable at the early time of bone formation. At the later stage, both Bio-Oss and OHA can repair bone defects and guide bone regeneration, and the potential bone formation ability of OHA is better.