A Critical Role for IL4 in the Neonate after Exposure to Aerosolized Ovalbumin in a Murine Model of Allergen Sensitization

A Critical Role for IL4 in the Neonate after Exposure to Aerosolized Ovalbumin in a Murine Model of Allergen Sensitization

Results Mice exposed to aerosolized OVA as neonates were primed for a Th2 response with elevated levels of eosinophils, OVA specific IgE and Th2 cytokines (IL4, 5, 10, 13) but no detectable levels of IFN-gamma.

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Veröffentlicht in:Journal of allergy and clinical immunology 2015-02, Vol.135 (2), p.AB146-AB146
Hauptverfasser: Seymour, Brian W.P., PhD, Coffman, Robert L., PhD
Format: Artikel
Sprache:eng
Schlagworte:
Allergies
Allergy and Immunology
Medical research
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Zusammenfassung:Results Mice exposed to aerosolized OVA as neonates were primed for a Th2 response with elevated levels of eosinophils, OVA specific IgE and Th2 cytokines (IL4, 5, 10, 13) but no detectable levels of IFN-gamma.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2014.12.1415