The effect of chronic stress on anti-angiogenesis of sunitinib in colorectal cancer models

Highlights • The experiments were conducted in the context of a colorectal cancer model in mice. • Psychological stress attenuated the anti-angiogenic activity of sunitinib. • Norepinephrine increased the expression of VEGF and IL-8 stimulating angiogenesis. • The β-adrenoceptor–cAMP–PKA signaling p...

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Veröffentlicht in:	Psychoneuroendocrinology 2015-02, Vol.52, p.130-142
Hauptverfasser:	Liu, Jie, Deng, Guo-Hua, Zhang, Jie, Wang, Ying, Xia, Xiang-Yu, Luo, Xin-Mei, Deng, Yao-Tiao, He, Sha-Sha, Mao, Yin-Yan, Peng, Xing-Chen, Wei, Yu-Quan, Jiang, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - metabolism Adrenoceptor Angiogenesis Inhibitors - pharmacology Animals Anti-angiogenic therapy Cell Line, Tumor Chronic Disease Chronic stress Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Disease Models, Animal Endocrinology & Metabolism Female Humans Indoles - pharmacology Interleukin-8 - metabolism Mice Mice, Inbred BALB C Norepinephrine Norepinephrine - metabolism Psychiatry Pyrroles - pharmacology Receptors, Adrenergic, beta - metabolism Signal Transduction Stress, Psychological Sunitinib Vascular Endothelial Growth Factor A - metabolism
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Zusammenfassung:	Highlights • The experiments were conducted in the context of a colorectal cancer model in mice. • Psychological stress attenuated the anti-angiogenic activity of sunitinib. • Norepinephrine increased the expression of VEGF and IL-8 stimulating angiogenesis. • The β-adrenoceptor–cAMP–PKA signaling pathway played an important role. • Beta-blockers might improve anti-angiogenic outcome under psychological stress.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2014.11.008