Stimulation of the histamine 4 receptor with 4-methylhistamine modulates the effects of chronic stress on the Th1/Th2 cytokine balance

Highlights • We investigated potential anti-stress effects downstream of the H4R. • 4-MeH significantly increases CD4+ T cell production in restraint-induced stress. • There was skewing toward Th1 cells following 4-MeH treatment of stressed mice. • Addition of 4-MeH increases expression of GITR, TNF...

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Veröffentlicht in:	Immunobiology (1979) 2015-03, Vol.220 (3), p.341-349
Hauptverfasser:	Ahmad, Sheikh Fayaz, Zoheir, Khairy M.A, Ansari, Mushtaq Ahmad, Korashy, Hesham M, Bakheet, Saleh A, Ashour, Abdelkader E, Attia, Sabry M
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Methylhistamine dihydrochloride Advanced Basic Science Allergy and Immunology Animals Chronic stress Cytokines Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+) - genetics Histamine 4 receptor Histamine Agonists - pharmacology Interferon-gamma - blood Interferon-gamma - genetics Interleukin-1beta - genetics Interleukin-4 - blood Lymphocyte Activation - immunology Lymphocyte Count Male Methylhistamines - pharmacology Mice Mice, Inbred BALB C Protein and mRNA expression levels Receptors, Histamine - immunology Restraint, Physical RNA, Messenger - biosynthesis Spleen - immunology Stress, Physiological - immunology Th1 Cells - immunology Th1-Th2 Balance - drug effects Th2 Cells - immunology Tumor Necrosis Factor-alpha - genetics Up-Regulation
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Beschreibung
Zusammenfassung:	Highlights • We investigated potential anti-stress effects downstream of the H4R. • 4-MeH significantly increases CD4+ T cell production in restraint-induced stress. • There was skewing toward Th1 cells following 4-MeH treatment of stressed mice. • Addition of 4-MeH increases expression of GITR, TNF-α, IFN-γ, and Ox40 proteins.
ISSN:	0171-2985 1878-3279
DOI:	10.1016/j.imbio.2014.10.014