Assessment of pulmonary toxicity of MgO nanoparticles in rats

In this study, we have evaluated the pulmonary toxicity of MgO nanoparticles (MgO NPs) in rats following their exposure. NPs in phosphate buffered saline + 1% Tween 80 were exposed via intratracheal instillation at a doses of 1 mg/kg or 5 mg/kg into rat lungs and evaluated for various tissue damage...

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Veröffentlicht in:	Environmental toxicology 2015-03, Vol.30 (3), p.308-314
Hauptverfasser:	Gelli, Kiranmai, Porika, Mahendar, Anreddy, Rama Narsimha Reddy
Format:	Artikel
Sprache:	eng
Schlagworte:	alkaline phosphatase Alkaline Phosphatase - metabolism ALP Animals BAL fluid Bronchoalveolar Lavage Fluid - cytology dose response Dose-Response Relationship, Drug histology histopathology L-Lactate Dehydrogenase - metabolism lactate dehydrogenase LDH Lung - pathology Lung Diseases - chemically induced Lung Diseases - pathology lungs lymphocytes magnesium oxide Magnesium Oxide - toxicity Male MgO nanoparticles Nanoparticles - toxicity Neutrophil Infiltration - drug effects PBS polysorbates Quartz Quartz - toxicity Rats Rats, Wistar toxicity
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Beschreibung
Zusammenfassung:	In this study, we have evaluated the pulmonary toxicity of MgO nanoparticles (MgO NPs) in rats following their exposure. NPs in phosphate buffered saline + 1% Tween 80 were exposed via intratracheal instillation at a doses of 1 mg/kg or 5 mg/kg into rat lungs and evaluated for various tissue damage markers like alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) in bronchoalveolar lavage (BAL) fluid and histopathology of lungs at 1, 7, and 30 days of post‐exposure intervals. A dose‐dependant increase in ALP and LDH activity was observed in BAL fluids of rat lungs than sham control at all post‐exposure periods (P
ISSN:	1520-4081 1522-7278
DOI:	10.1002/tox.21908