H-PGD Synthase (H-PGDS) Gene Expression Increases in Eosinophils of Aspirin Exacerbated Respiratory Disease (AERD) Patients after Oral Graded Aspirin Challenge

H-PGD Synthase (H-PGDS) Gene Expression Increases in Eosinophils of Aspirin Exacerbated Respiratory Disease (AERD) Patients after Oral Graded Aspirin Challenge

Rationale 10% of adult asthmatics suffer from AERD, characterized by adult onset of moderate to severe asthma and nasal polyps, peripheral and tissue eosinophilia, and a hypersensitivity reaction (bronchospasm, rhinorrhea, and/or conjunctivitis) in response to cyclooxygenase-1 (COX-1) inhibition.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of allergy and clinical immunology 2015-02, Vol.135 (2), p.AB160-AB160
Hauptverfasser: Jerschow, Elina, MD, MSc, Zhen, Ren, Schuster, Victor, MD, Rosenstreich, David L., MD, FAAAAI, Spivack, Simon, MD, MPH
Format: Artikel
Sprache:eng
Schlagworte:
Allergies
Allergy and Immunology
Aspirin
Gene expression
Urine
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Zusammenfassung:Rationale 10% of adult asthmatics suffer from AERD, characterized by adult onset of moderate to severe asthma and nasal polyps, peripheral and tissue eosinophilia, and a hypersensitivity reaction (bronchospasm, rhinorrhea, and/or conjunctivitis) in response to cyclooxygenase-1 (COX-1) inhibition.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2014.12.1462