Therapeutic outcomes of combining cryotherapy, chemotherapy and DC-CIK immunotherapy in the treatment of metastatic non-small cell lung cancer

Currently there are no effective therapies for the treatment of metastatic non-small cell lung cancer (NSCLC). Here, we conducted a retrospective study of 161 patients to evaluate the therapeutic effects of combining cryosurgery, chemotherapy and dendritic cell-activated cytokine-induced killer cell...

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Veröffentlicht in:	Cryobiology 2013-10, Vol.67 (2), p.235-240
Hauptverfasser:	Yuanying, Yuan, Lizhi, Niu, Feng, Mu, Xiaohua, Wang, Jianying, Zeng, Fei, Yao, Feng, Jiang, Lihua, He, Jibing, Chen, Jialiang, Li, Kecheng, Xu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Agents - therapeutic use Carcinoma, Non-Small-Cell Lung - immunology Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - surgery Carcinoma, Non-Small-Cell Lung - therapy Chemotherapy Combined Modality Therapy - methods Combined therapy Cryosurgery - methods Cryotherapy Cytokine-Induced Killer Cells - immunology Cytokine-Induced Killer Cells - transplantation Dendritic Cells - immunology Drug Therapy - methods Female Humans Immunotherapy Immunotherapy - methods Lung Neoplasms - immunology Lung Neoplasms - pathology Lung Neoplasms - surgery Lung Neoplasms - therapy Male Metastatic NSCLC Middle Aged Retrospective Studies Treatment Outcome
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Zusammenfassung:	Currently there are no effective therapies for the treatment of metastatic non-small cell lung cancer (NSCLC). Here, we conducted a retrospective study of 161 patients to evaluate the therapeutic effects of combining cryosurgery, chemotherapy and dendritic cell-activated cytokine-induced killer cells (DC-CIK) immunotherapy. The overall survival (OS) after diagnosis of metastatic NSCLC to patient death was assessed during a 5-years follow-up period. OS of patients who received comprehensive cryotherapy was (median OS, 20months; n=86) significantly longer than that of patients who did not received cryotherapy (median OS, 10months; n=75; P
ISSN:	0011-2240 1090-2392
DOI:	10.1016/j.cryobiol.2013.08.001