A prodrug strategy for the oral delivery of a poorly soluble HCV NS5B thumb pocket 1 polymerase inhibitor using self-emulsifying drug delivery systems (SEDDS)

A prodrug strategy for the oral delivery of a poorly soluble HCV NS5B thumb pocket 1 polymerase inhibitor using self-emulsifying drug delivery systems (SEDDS)

A prodrug approach was developed to address the low oral bioavailability of a poorly soluble (

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Bibliographische Detailangaben
Veröffentlicht in:Bioorganic & medicinal chemistry letters 2015-01, Vol.25 (2), p.210-215
Hauptverfasser: Beaulieu, Pierre L, De Marte, Josie, Garneau, Michel, Luo, Laibin, Stammers, Timothy, Telang, Chitra, Wernic, Dominik, Kukolj, George, Duan, Jianmin
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Oral
Animals
Drug Delivery Systems - methods
Emulsions - administration & dosage
Emulsions - chemistry
Emulsions - metabolism
Hepatitis C virus
Microsomes - drug effects
Microsomes - metabolism
Nucleic Acid Synthesis Inhibitors - administration & dosage
Nucleic Acid Synthesis Inhibitors - chemistry
Nucleic Acid Synthesis Inhibitors - metabolism
Prodrugs - administration & dosage
Prodrugs - chemistry
Prodrugs - metabolism
Rats
Solubility
Viral Nonstructural Proteins - antagonists & inhibitors
Viral Nonstructural Proteins - metabolism
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Zusammenfassung:A prodrug approach was developed to address the low oral bioavailability of a poorly soluble (
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2014.11.071