Substance P (subP) and Minocycline Suppress Induction of Human Ragweed Specific Memory IgE Responses By Different Mechanisms

Substance P (subP) and Minocycline Suppress Induction of Human Ragweed Specific Memory IgE Responses By Different Mechanisms

Rationale We reported that CD4+ and CD8+CD60+ T cells and 6 cytokines, including IL-4, were required for ragweed specific (RS) memory IgE responses by PBMC of ragweed sensitized humans, and that minocycline strongly suppressed T cell expression of phosphorylated p38 MAP kinase (p38MAPK) and IL-4, wh...

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Veröffentlicht in:Journal of allergy and clinical immunology 2015-02, Vol.135 (2), p.AB67-AB67
Hauptverfasser: Kim, Charles J., BS, McCarthy, Bryan, BS, Chice, Seto M., MS, Nowakowski, Maja, PhD, Silverberg, Jonathan, MD, PhD, MPH, Kohlhoff, Stephan A., MD, Joks, Rauno O., MD, FAAAAI, Smith-Norowitz, Tamar A., PhD, Durkin, Helen G., PhD
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Cytokines
Lymphocytes
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Zusammenfassung:Rationale We reported that CD4+ and CD8+CD60+ T cells and 6 cytokines, including IL-4, were required for ragweed specific (RS) memory IgE responses by PBMC of ragweed sensitized humans, and that minocycline strongly suppressed T cell expression of phosphorylated p38 MAP kinase (p38MAPK) and IL-4, while preventing induction of RS memory IgE responses.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2014.12.1151