How Well Does Whole Genome Sequencing Improve Ability to Detect Association with Asthma in Candidate Genes Compared to Existing GWAS Platforms in African American Populations?

How Well Does Whole Genome Sequencing Improve Ability to Detect Association with Asthma in Candidate Genes Compared to Existing GWAS Platforms in African American Populations?

Because current GWAS arrays are inadequate for African populations, we propose analyzing candidate genes in CAAPA will help detect new variants associated with asthma.

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Veröffentlicht in:Journal of allergy and clinical immunology 2015-02, Vol.135 (2), p.AB164-AB164
Hauptverfasser: Rafaels, Nicholas M., MS, Johnston, Henry R, Huang, Lili, MPH, Chavan, Sameer, MS, Wilson, James G., MD, Williams, L. Keoki, MD, MPH, FAAAAI, Ware, Lorraine B., MD, Ober, Carole, PhD, Meyers, Deborah A., PhD, FAAAAI, Hartert, Tina V., MD MPH, Foreman, Marilyn, MD, MS, Ford, Jean G., MD, Burchard, Esteban Gonza, MD, MPH, Bleecker, Eugene R., MD, FAAAAI, Taub, Margaret, PhD, Beaty, Terri H., PhD, Ruczinski, Ingo, PhD, Mathias, Rasika A., ScD, Barnes, Kathleen C., PhD, FAAAAI
Format: Artikel
Sprache:eng
Schlagworte:
African Americans
Allergy and Immunology
Asthma
Genealogy
Genes
Genomes
Genomics
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Zusammenfassung:Because current GWAS arrays are inadequate for African populations, we propose analyzing candidate genes in CAAPA will help detect new variants associated with asthma.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2014.12.1473