The tight junction protein JAM-A functions as coreceptor for rotavirus entry into MA104 cells

Abstract Several molecules have been identified as receptors or coreceptors for rotavirus infection, including glycans, integrins, and hsc70. In this work we report that the tight junction proteins JAM-A, occludin, and ZO-1 play an important role during rotavirus entry into MA104 cells. JAM-A was fo...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2015-01, Vol.475, p.172-178
Hauptverfasser:	Torres-Flores, Jesús M, Silva-Ayala, Daniela, Espinoza, Marco A, López, Susana, Arias, Carlos F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Humans Infectious Disease JAM-A Macaca mulatta Mice Occludin Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism RNA Interference RNA, Small Interfering Rotavirus Rotavirus - physiology Tight junction proteins Tight Junction Proteins - genetics Tight Junction Proteins - metabolism Virus entry Virus Internalization ZO-1
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Zusammenfassung:	Abstract Several molecules have been identified as receptors or coreceptors for rotavirus infection, including glycans, integrins, and hsc70. In this work we report that the tight junction proteins JAM-A, occludin, and ZO-1 play an important role during rotavirus entry into MA104 cells. JAM-A was found to function as coreceptor for rotavirus strains RRV, Wa, and UK, but not for rotavirus YM. Reassortant viruses derived from rotaviruses RRV and YM showed that the virus spike protein VP4 determines the use of JAM-A as coreceptor.
ISSN:	0042-6822 1096-0341
DOI:	10.1016/j.virol.2014.11.016