Prompt Diagnosis of Autosomal Dominant Hyper IgE Syndrome Leads to Reduced Infection and Improved Clinical Phenotype

Prompt Diagnosis of Autosomal Dominant Hyper IgE Syndrome Leads to Reduced Infection and Improved Clinical Phenotype

Rationale Dominant negative mutations in STAT3 lead to elevated serum IgE, eczema, and recurrent skin and lung infections, known as autosomal dominant Hyper IgE Syndrome (AD-HIES).

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Bibliographische Detailangaben
Veröffentlicht in:Journal of allergy and clinical immunology 2015-02, Vol.135 (2), p.AB183-AB183
Hauptverfasser: Williams, Kelli W., MD, MPH, McGowan, Katherine, BS, Sowerwine, Kathryn J., MD, Davis, Joie, PNP, Holland, Steven M., MD, Freeman, Alexandra F., MD
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Eczema
Genotype & phenotype
Medical research
Pneumonia
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Beschreibung
Zusammenfassung:Rationale Dominant negative mutations in STAT3 lead to elevated serum IgE, eczema, and recurrent skin and lung infections, known as autosomal dominant Hyper IgE Syndrome (AD-HIES).
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2014.12.1531