Release of High-Mobility Group Box-1 (HMGB1) in the Airways of Children with Viral Lower Respiratory Tract Infections

Release of High-Mobility Group Box-1 (HMGB1) in the Airways of Children with Viral Lower Respiratory Tract Infections

Conclusions Greater levels of HMGB1 in infants with RSV bronchiolitis correlate with inflammatory chemokines that are produced by or activate macrophages suggesting that HMGB1 represents a marker of disease severity and/or directly contributes to the pathogenesis of such infection.

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Veröffentlicht in:Journal of allergy and clinical immunology 2015-02, Vol.135 (2), p.AB230-AB230
Hauptverfasser: Schlegel, Chelsea R, Ivanciuc, Teodora, PhD, Garofalo, Roberto P., MD, Palkowetz, Kimberly H, Fuller, Kelly A, Kelley, John P., MD, Gupta, Meera Rani, MD, Casola, Antonella, MD
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Chemokines
Infections
Medical research
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Zusammenfassung:Conclusions Greater levels of HMGB1 in infants with RSV bronchiolitis correlate with inflammatory chemokines that are produced by or activate macrophages suggesting that HMGB1 represents a marker of disease severity and/or directly contributes to the pathogenesis of such infection.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2014.12.1686