Antitumor effect of boron nitride nanotubes in combination with thermal neutron irradiation on BNCT

The first BNCT antitumor effects of BNNTs toward B16 melanoma cells were demonstrated. The use of DSPE-PEG2000 was effective for preparation of the BNNT-suspended aqueous solution. BNNT-DSPE-PEG2000 accumulated in B16 melanoma cells approximately three times higher than BSH and the higher BNCT antit...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2015-01, Vol.25 (2), p.172-174
Hauptverfasser:	Nakamura, Hiroyuki, Koganei, Hayato, Miyoshi, Tatsuro, Sakurai, Yoshinori, Ono, Koji, Suzuki, Minoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Boron Compounds - administration & dosage Boron Compounds - chemistry Boron Neutron Capture Therapy - methods Cell Survival - drug effects Cell Survival - radiation effects Melanoma, Experimental - drug therapy Melanoma, Experimental - radiotherapy Nanotubes - chemistry Neutrons Skin Neoplasms - drug therapy Skin Neoplasms - radiotherapy
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Zusammenfassung:	The first BNCT antitumor effects of BNNTs toward B16 melanoma cells were demonstrated. The use of DSPE-PEG2000 was effective for preparation of the BNNT-suspended aqueous solution. BNNT-DSPE-PEG2000 accumulated in B16 melanoma cells approximately three times higher than BSH and the higher BNCT antitumor effect was observed in the cells treated with BNNT-DSPE-PEG2000 compared to those treated with BSH, indicating that BNNT-DSPE-PEG2000 would be a possible candidate as a boron delivery vehicle for BNCT.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2014.12.005