Design, synthesis and biological evaluation of novel arylpiperazine derivatives on human prostate cancer cell lines

A series of novel arylpiperazine derivatives was synthesized. The in vitro cytotoxic activities of all synthesized compounds against three human prostate cancer cell lines (PC-3, LNCaP, and DU145) were evaluated by a CCK-8 assay. Compounds 10, 24 and 29 exhibited strong cytotoxic activities against...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2015-01, Vol.25 (2), p.285-287
Hauptverfasser:	Chen, Hong, Xu, Fang, Liang, Xue, Xu, Bing-Bing, Yang, Zong-Lin, He, Xue-Lan, Huang, Bi-Yun, Yuan, Mu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Cell Proliferation - drug effects Drug Design Drug Screening Assays, Antitumor Humans Male Models, Molecular Molecular Structure Piperazines - chemical synthesis Piperazines - pharmacology Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Structure-Activity Relationship Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	A series of novel arylpiperazine derivatives was synthesized. The in vitro cytotoxic activities of all synthesized compounds against three human prostate cancer cell lines (PC-3, LNCaP, and DU145) were evaluated by a CCK-8 assay. Compounds 10, 24 and 29 exhibited strong cytotoxic activities against LNCaP cells (IC50
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2014.11.049