Development and Characterization of an Anti-FXIIa Monoclonal Antibody for the Treatment of Hereditary Angioedema

Development and Characterization of an Anti-FXIIa Monoclonal Antibody for the Treatment of Hereditary Angioedema

Administration of 3F7 abrogated skin edema induced by contact activation triggered by mast-cell released heparin in mice. 3F7 was also shown to abolish bradykinin-mediated increase of vascular permeability induced by the angiotensin-converting enzyme (ACE) inhibitor captopril in C1-inhibitor deficie...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of allergy and clinical immunology 2015-02, Vol.135 (2), p.AB194-AB194
Hauptverfasser: Cao, Zhihui (Helen), Biondo, Mark, Rayzman, Veronika, Hardy, Matthew, McDonald, Anne, Busfield, Samantha, Nolte, Marc W, Wilson, Michael, Nash, Andrew, Panousis, Con
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Enzymes
Medical research
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Administration of 3F7 abrogated skin edema induced by contact activation triggered by mast-cell released heparin in mice. 3F7 was also shown to abolish bradykinin-mediated increase of vascular permeability induced by the angiotensin-converting enzyme (ACE) inhibitor captopril in C1-inhibitor deficient mice.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2014.12.1570