Intracellular sensing of viral DNA by the innate immune system
Recent years have seen a great advance in knowledge of how a host senses infection. Nucleic acids, as a common denominator to all pathogens, are at the centre of several of the sensing pathways, especially those involved with the recognition of viruses. In this review we discuss the current knowledg...
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| Veröffentlicht in: | Microbes and infection 2014-12, Vol.16 (12), p.1002-1012 |
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| container_title | Microbes and infection |
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| creator | Mansur, Daniel S. Smith, Geoffrey L. Ferguson, Brian J. |
| description | Recent years have seen a great advance in knowledge of how a host senses infection. Nucleic acids, as a common denominator to all pathogens, are at the centre of several of the sensing pathways, especially those involved with the recognition of viruses. In this review we discuss the current knowledge on how intracellular DNA is sensed by the mammalian host. |
| doi_str_mv | 10.1016/j.micinf.2014.09.010 |
| format | Article |
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| ispartof | Microbes and infection, 2014-12, Vol.16 (12), p.1002-1012 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Autoimmunity Autoinflammation DNA sensing DNA, Viral - immunology Host-Pathogen Interactions Humans Immune Evasion Immunity, Innate - physiology Intracellular Space - metabolism Signal Transduction Type one interferon Vaccines Viral Vaccines - genetics Viral Vaccines - immunology Virus Diseases - immunology Virus Diseases - metabolism Virus Diseases - prevention & control Virus recognition Viruses - genetics Viruses - immunology |
| title | Intracellular sensing of viral DNA by the innate immune system |
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