Intracellular sensing of viral DNA by the innate immune system

Recent years have seen a great advance in knowledge of how a host senses infection. Nucleic acids, as a common denominator to all pathogens, are at the centre of several of the sensing pathways, especially those involved with the recognition of viruses. In this review we discuss the current knowledg...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Microbes and infection 2014-12, Vol.16 (12), p.1002-1012
Hauptverfasser:	Mansur, Daniel S., Smith, Geoffrey L., Ferguson, Brian J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmunity Autoinflammation DNA sensing DNA, Viral - immunology Host-Pathogen Interactions Humans Immune Evasion Immunity, Innate - physiology Intracellular Space - metabolism Signal Transduction Type one interferon Vaccines Viral Vaccines - genetics Viral Vaccines - immunology Virus Diseases - immunology Virus Diseases - metabolism Virus Diseases - prevention & control Virus recognition Viruses - genetics Viruses - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Recent years have seen a great advance in knowledge of how a host senses infection. Nucleic acids, as a common denominator to all pathogens, are at the centre of several of the sensing pathways, especially those involved with the recognition of viruses. In this review we discuss the current knowledge on how intracellular DNA is sensed by the mammalian host.
ISSN:	1286-4579 1769-714X
DOI:	10.1016/j.micinf.2014.09.010