Ultralow-intensity near-infrared light induces drug delivery by upconverting nanoparticles

Ultralow-intensity near-infrared light induces drug delivery by upconverting nanoparticles

Mesoporous silica coated upconverting nanoparticles are loaded with the anticancer drug doxorubicin and grafted with ruthenium complexes as photoactive molecular valves. Drug release was triggered by 974 nm light with 0.35 W cm(-2). Such low light intensity minimized overheating problems and prevent...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-01, Vol.51 (2), p.431-434
Hauptverfasser: He, Shuqing, Krippes, Kristina, Ritz, Sandra, Chen, Zhijun, Best, Andreas, Butt, Hans-Jürgen, Mailänder, Volker, Wu, Si
Format: Artikel
Sprache:eng
Schlagworte:
Coating
Doxorubicin
Drug delivery systems
Nanoparticles
Overheating
Ruthenium
Silicon dioxide
Valves
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Zusammenfassung:Mesoporous silica coated upconverting nanoparticles are loaded with the anticancer drug doxorubicin and grafted with ruthenium complexes as photoactive molecular valves. Drug release was triggered by 974 nm light with 0.35 W cm(-2). Such low light intensity minimized overheating problems and prevented photodamage to biological samples.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc07489k