Efficient Delivery of Therapeutic miRNA Nanocapsules for Tumor Suppression

miRNA nanocapsules are synthesized with enhanced stability for miRNA delivery with high transduction efficiency, offering a novel class of miRNA vectors for cancer therapy.

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Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Weinheim) 2015-01, Vol.27 (2), p.292-297
Hauptverfasser:	Liu, Chaoyong, Wen, Jing, Meng, Yubin, Zhang, Kailiang, Zhu, Jialin, Ren, Yu, Qian, Xiaomin, Yuan, Xubo, Lu, Yunfeng, Kang, Chunsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamide - chemistry angiogenesis Animals Cancer cancer therapy Cell Line, Tumor Cell Survival Gene Knockdown Techniques Genetic Therapy - instrumentation Genetic Therapy - methods Human Umbilical Vein Endothelial Cells Humans Kinetics Mathematical analysis Methacrylates - chemistry Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism MicroRNAs - therapeutic use miR-21 miRNA delivery nanocapsules Nanocapsules - therapeutic use Nanostructure Neoplasm Transplantation Neoplasms - physiopathology Neoplasms - therapy Polymerization Ribonucleic acids RNA, Antisense - metabolism RNA, Antisense - therapeutic use Stability Therapy Transduction, Genetic Tumors Vectors (mathematics)
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Beschreibung
Zusammenfassung:	miRNA nanocapsules are synthesized with enhanced stability for miRNA delivery with high transduction efficiency, offering a novel class of miRNA vectors for cancer therapy.
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.201403387