Water Proton Relaxivity, Superoxide Dismutase-like Activity, and Cytotoxicity of a Manganese(III) Porphyrin Having Four Poly(ethylene glycol) Tails

Water Proton Relaxivity, Superoxide Dismutase-like Activity, and Cytotoxicity of a Manganese(III) Porphyrin Having Four Poly(ethylene glycol) Tails

A high-molecular-weight water-soluble manganese(III) porphyrin having four poly(ethylene glycol) tails was prepared, which enhanced the T1 relaxation rate of water protons by ca. 7.5-fold compared with manganese(III)–tetra(4-sulfonatophenyl)porphyrin. The new compound also exhibited superoxide dismu...

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Veröffentlicht in:Chemistry letters 2014-05, Vol.43 (5), p.732-734
Hauptverfasser: Hitomi, Yutaka, Ekawa, Tomoyuki, Kodera, Masahito
Format: Artikel
Sprache:eng
Schlagworte:
Glycols
Porphyrins
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Zusammenfassung:A high-molecular-weight water-soluble manganese(III) porphyrin having four poly(ethylene glycol) tails was prepared, which enhanced the T1 relaxation rate of water protons by ca. 7.5-fold compared with manganese(III)–tetra(4-sulfonatophenyl)porphyrin. The new compound also exhibited superoxide dismutase-like activity and significantly lower cytotoxicity.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.140029