A folic acid conjugated silica-titania porous hollow nanosphere for improved topical photodynamic therapy

The folic acid conjugated hollow nanosphere is used to encapsulate protoporphyrin IX and is utilized for photodynamic therapy. This system represents a 3.33 times higher photodynamic efficiency than previous protoporphyrin IX-based systems. The result proposes a new opportunity for effective photody...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2014-12, Vol.50 (97), p.15345-15347
Hauptverfasser:	Jang, Yoonsun, Kim, Sojin, Oh, Wan-Kyu, Kim, Chanhoi, Lee, Inkyu, Jang, Jyongsik
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cell Survival - drug effects Drug Carriers - administration & dosage Drug Carriers - chemistry Encapsulation Folate Receptors, GPI-Anchored - metabolism Folic acid Folic Acid - administration & dosage Folic Acid - chemistry Humans MCF-7 Cells Microscopy, Electron, Transmission Nanospheres - administration & dosage Nanospheres - chemistry Nanospheres - ultrastructure Nanostructure Photochemotherapy Photodynamic therapy Photosensitizing Agents - administration & dosage Photosensitizing Agents - chemistry Porosity Protoporphyrins - administration & dosage Protoporphyrins - chemistry Reactive Oxygen Species - metabolism Receptors Silicon Dioxide - chemistry Titanium - administration & dosage Titanium - chemistry Tumors
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Beschreibung
Zusammenfassung:	The folic acid conjugated hollow nanosphere is used to encapsulate protoporphyrin IX and is utilized for photodynamic therapy. This system represents a 3.33 times higher photodynamic efficiency than previous protoporphyrin IX-based systems. The result proposes a new opportunity for effective photodynamic therapy of folate receptor positive tumor cells.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c4cc07457b