Evaluation of the cytotoxic and mutagenic potential of three ginkgolic acids

Evaluation of the cytotoxic and mutagenic potential of three ginkgolic acids

Highlights • We analyzed the cytotoxicity of three major ginkgolic acids (GAs) in V79 cells. • We investigated the mutagenicity of the three GAs in the Ames fluctuation assay. • We analyzed the genotoxicity of the three GAs in the HPRT assay in V79 cells. • We found that the GAs were cytotoxic but n...

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Veröffentlicht in:Toxicology (Amsterdam) 2015-01, Vol.327, p.47-52
Hauptverfasser: Berg, Kerstin, Braun, Christine, Krug, Isabel, Schrenk, Dieter
Format: Artikel
Sprache:eng
Schlagworte:
Activation
Ames’ test
Animals
Assaying
Cell Line
Cell Survival - drug effects
Cricetinae
Cricetulus
Cytotoxicity
Drugs
Emergency
Extraction plants
Fibroblasts
Ginkgo biloba
Ginkgoaceae
Ginkgobiloba
Ginkgolic acids
HPRT assay
Hypoxanthine Phosphoribosyltransferase - genetics
Male
Mutagenicity
Mutagenicity Tests
Mutagens - toxicity
Reduction
Salicylates - chemistry
Salicylates - toxicity
Salmonella typhimurium
Therapy
Toxicity Tests
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Zusammenfassung:Highlights • We analyzed the cytotoxicity of three major ginkgolic acids (GAs) in V79 cells. • We investigated the mutagenicity of the three GAs in the Ames fluctuation assay. • We analyzed the genotoxicity of the three GAs in the HPRT assay in V79 cells. • We found that the GAs were cytotoxic but not genotoxic.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2014.10.001