Multifunctional "Smart" Particles Engineered from Live Immunocytes: Toward Capture and Release of Cancer Cells

Multifunctional "Smart" Particles Engineered from Live Immunocytes: Toward Capture and Release of Cancer Cells

Multifunctional “smart” particles with magnetic, topographic, cell‐targeting, and stimulus‐responsive properties are obtained using a “live template” strategy. These particles exhibit improved efficiency in capture of target cancer cells by introducing synergistic topographic interactions, and enabl...

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Veröffentlicht in:Advanced materials (Weinheim) 2015-01, Vol.27 (2), p.310-313
Hauptverfasser: Huang, Chao, Yang, Gao, Ha, Qing, Meng, Jinxin, Wang, Shutao
Format: Artikel
Sprache:eng
Schlagworte:
"live template"
"smart" particles
Animals
Biomimetic Materials - chemistry
Blood Cells - physiology
Cancer
cell capture
Cell Engineering - instrumentation
Cell Engineering - methods
cell release
Cell Survival
Disulfides
Endocytosis
HeLa Cells
Humans
Jurkat Cells
Macrophages - physiology
Magnetic properties
Magnetite Nanoparticles
MCF-7 Cells
Neoplasms - physiopathology
Neoplasms - therapy
Phagocytosis - physiology
Rats
Reduction
Silicon Dioxide - chemistry
Strategy
topographic structures
Viability
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Zusammenfassung:Multifunctional “smart” particles with magnetic, topographic, cell‐targeting, and stimulus‐responsive properties are obtained using a “live template” strategy. These particles exhibit improved efficiency in capture of target cancer cells by introducing synergistic topographic interactions, and enable the release of captured cells with high viability via reduction of disulfide bonds. Diverse multifunctional particles can be designed using the “live template” strategy.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201402213