In vitro endocrine disruption potential of organophosphate flame retardants via human nuclear receptors

Highlights • Nuclear receptor activities of OPFRs were studied by in vitro reporter gene assays. • TPhP and TCP acted as ERα/β and PXR agonists as well as AR and GR antagonists. • TDCPP was the most potent AR antagonist among the tested OPFRs. • None of the OPFRs had TRα/β, RARα, RXRα, or PPARα/γ ac...

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Veröffentlicht in:	Toxicology (Amsterdam) 2013-12, Vol.314 (1), p.76-83
Hauptverfasser:	Kojima, Hiroyuki, Takeuchi, Shinji, Itoh, Toshihiro, Iida, Mitsuru, Kobayashi, Satoshi, Yoshida, Takahiko
Format:	Artikel
Sprache:	eng
Schlagworte:	androgen receptors Animals beta-Galactosidase - metabolism buildings Cercopithecus aethiops CHO Cells construction materials COS Cells Cricetinae Cricetulus Dose-Response Relationship, Drug Emergency Endocrine Disruptors estrogen receptors fabrics Flame retardant Flame retardants Flame Retardants - toxicity Genes, Reporter - drug effects glucocorticoid receptors Houses Human Humans Nuclear receptor Organophosphate Organophosphates Organophosphorus Compounds - toxicity Phosphates Plasmids - genetics pollution Receptors Receptors, Cytoplasmic and Nuclear - agonists Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors Receptors, Cytoplasmic and Nuclear - drug effects Reporter gene assay retinoic acid TCP (protocol) Textiles thyroid hormone receptors toxicology Transcription, Genetic - drug effects transcriptional activation
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Zusammenfassung:	Highlights • Nuclear receptor activities of OPFRs were studied by in vitro reporter gene assays. • TPhP and TCP acted as ERα/β and PXR agonists as well as AR and GR antagonists. • TDCPP was the most potent AR antagonist among the tested OPFRs. • None of the OPFRs had TRα/β, RARα, RXRα, or PPARα/γ activity. • Several OPFRs might be endocrine disruptors via ERα/β, AR, GR, or PXR.
ISSN:	0300-483X 1879-3185
DOI:	10.1016/j.tox.2013.09.004