Fructose-coated nanoparticles: a promising drug nanocarrier for triple-negative breast cancer therapy

Fructose transporter GLUT5 is overexpressed in breast cancer cell lines, but not in healthy tissue. Micelles based on fructose, which were found to be low fouling, showed a high uptake by breast cancer cells (MCF-7 and MDA-MB-231 cells), but only negligible uptake by macrophages.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2014-12, Vol.50 (100), p.15928-15931
Hauptverfasser:	Zhao, Jiacheng, Babiuch, Krzysztof, Lu, Hongxu, Dag, Aydan, Gottschaldt, Michael, Stenzel, Martina H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Biotechnology Breast Cancer Cell Line, Tumor CHO Cells Cricetinae Cricetulus Female Flow Cytometry Fructose Fructose - chemistry Glucose Transporter Type 5 - metabolism Humans MCF-7 Cells Mice Micelles Microscopy, Confocal Nanoparticles Nanoparticles - chemistry Nanoparticles - metabolism Nanostructure Polymers - chemistry Protein Binding Transporter Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology Uptakes
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Beschreibung
Zusammenfassung:	Fructose transporter GLUT5 is overexpressed in breast cancer cell lines, but not in healthy tissue. Micelles based on fructose, which were found to be low fouling, showed a high uptake by breast cancer cells (MCF-7 and MDA-MB-231 cells), but only negligible uptake by macrophages.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c4cc06651k