Inflammatory modulation of stem cells by Magnetic Resonance Imaging (MRI)-detectable nanoparticles

Inflammatory modulation of stem cells by Magnetic Resonance Imaging (MRI)-detectable nanoparticles

In the current work, we labelled human hematopoietic stem cells with polymeric nanoparticles (NPs) that can be tracked by Magnetic Resonance Imaging (MRI) and studied their effect on cell metabolism, proliferation, secretomics, genomics and differentiation. We showed that NPs had no effect on the st...

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Veröffentlicht in:RSC advances 2014-01, Vol.4 (60), p.31706-31709
Hauptverfasser: Aday, Sezin, Paiva, Jose, Sousa, Susana, Gomes, Renata SM, Pedreiro, Susana, So, Po-Wah, Carr, Carolyn Ann, Cochlin, Lowri, Gomes, Ana Catarina, Paiva, Artur, Ferreira, Lino
Format: Artikel
Sprache:eng
Schlagworte:
Differentiation
Human
Magnetic resonance imaging
Metabolism
Modulation
Nanoparticles
Stem cells
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Zusammenfassung:In the current work, we labelled human hematopoietic stem cells with polymeric nanoparticles (NPs) that can be tracked by Magnetic Resonance Imaging (MRI) and studied their effect on cell metabolism, proliferation, secretomics, genomics and differentiation. We showed that NPs had no effect on the stem cell differentiation program but affected their paracrine activity.
ISSN:2046-2069
2046-2069
DOI:10.1039/c4ra04041d