Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics

Chlorzoxazone is mainly metabolized to 6-hydroxychlorzoxazone (6-OHchlorzoxazone) by the ethanol-inducible cytochrome P450 2E1 (CYP2E1). To evaluate the impact of ethanol consumption on the enzyme induction, the pharmacokinetics of chlorzoxazone and 6-OHchlorzoxazone were studied in alcoholic and co...

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Veröffentlicht in:	Biochemical pharmacology 1994-04, Vol.47 (9), p.1503-1508
Hauptverfasser:	Girre, Catherine, Lucas, Danièle, Hispard, Eric, Menez, Catherine, Dally, Sylvain, Menez, Jean-François
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alanine Transaminase - blood alcoholism Alcoholism - blood Alcoholism - enzymology Aspartate Aminotransferases - blood chlorzoxazone Chlorzoxazone - analogs & derivatives Chlorzoxazone - pharmacokinetics Cytochrome P-450 Enzyme System - biosynthesis cytochrome P4502E1 Enzyme Induction - drug effects gamma-Glutamyltransferase - blood Humans Male Metabolic Clearance Rate Middle Aged pharmacokinetics
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Zusammenfassung:	Chlorzoxazone is mainly metabolized to 6-hydroxychlorzoxazone (6-OHchlorzoxazone) by the ethanol-inducible cytochrome P450 2E1 (CYP2E1). To evaluate the impact of ethanol consumption on the enzyme induction, the pharmacokinetics of chlorzoxazone and 6-OHchlorzoxazone were studied in alcoholic and control subjects. Fifteen alcoholic male inpatients (all smokers, daily intake 333 ± 191 g of absolute ethanol) and 20 healthy male volunteers (10 smokers and 10 non-smokers, weekly intake
ISSN:	0006-2952 1873-2968
DOI:	10.1016/0006-2952(94)90524-X