Blood responses under chronic low daily dose gamma irradiation: II. Differential preclinical responses of irradiated female dogs in progression to either aplastic anemia or myeloproliferative disease

Female beagle dogs were chronically exposed to low daily doses of 60Co gamma rays (7.5 cGy day −1) and responded in one of three distinct hemopathological patterns. These patterns, reflective of distinct subgroups, were characterized by (a) low radioresistance resulting in progressive hematopoietic...

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Veröffentlicht in:Leukemia research 1993-05, Vol.17 (5), p.411-420
Hauptverfasser: Seed, Thomas, Carnes, Bruce, Tolle, David, Fritz, Thomas
Format: Artikel
Sprache:eng
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Zusammenfassung:Female beagle dogs were chronically exposed to low daily doses of 60Co gamma rays (7.5 cGy day −1) and responded in one of three distinct hemopathological patterns. These patterns, reflective of distinct subgroups, were characterized by (a) low radioresistance resulting in progressive hematopoietic suppression, terminal aplastic anemia (AA), and relatively short (
ISSN:0145-2126
1873-5835
DOI:10.1016/0145-2126(93)90096-4