Resistance to nitroprusside neurotoxicity in perinatal rat brain

Nitric oxide (NO) may mediate some of the toxic effects of the excitatory amino acid (EAA) glutamate when there is overactivation of the N- methyl- d-aspartate (NMDA) receptor. In the developing rodent nervous system, NMDA neurotoxicity peaks at postnatal day 7. To assess whether NO toxicity exhibit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience letters 1994-05, Vol.172 (1), p.80-84
Hauptverfasser:	Maragos, William F., Silverstein, Faye S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Animals, Newborn - physiology Biochemistry and metabolism Biological and medical sciences Brain Diseases - chemically induced Brain Diseases - pathology Central nervous system Free Radical Fundamental and applied biological sciences. Psychology Hippocampus - growth & development Hippocampus - pathology Injections Male Neostriatum - growth & development Neostriatum - pathology Neurotoxicity Nitric oxide Nitroprusside Nitroprusside - administration & dosage Nitroprusside - toxicity Perinatal Rats Rats, Sprague-Dawley Rodent Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Nitric oxide (NO) may mediate some of the toxic effects of the excitatory amino acid (EAA) glutamate when there is overactivation of the N- methyl- d-aspartate (NMDA) receptor. In the developing rodent nervous system, NMDA neurotoxicity peaks at postnatal day 7. To assess whether NO toxicity exhibits a similar developmental profile, we injected the NO generator sodium nitroprusside into the immature and adult rodent hippocampal formation and striatum, using a dose known to damage the adult nervous system. Contrary to our expectations, we found the immature brain highly resistant to the toxic effects of sodium nitroprusside.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(94)90667-X