Hyperkalemia and potential pitfalls of sodium polystyrene sulfonate

ABSTRACTSodium polystyrene sulfonate (SPS), FDA-approved more than 60 years ago for treating hyperkalemia, is an ion exchange resin that works by exchanging sodium for potassium in the colon. Though widely used in clinical practice, SPS use is not supported by well-designed clinical trials. In 2009,...

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Veröffentlicht in:	JAAPA (Montvale, N.J.) N.J.), 2015-03, Vol.28 (3), p.41-45
Hauptverfasser:	Nguyen, Timothy, Ondrik, Daniella, Zhufyak, Oksana, To, Watson, He, Sining
Format:	Artikel
Sprache:	eng
Schlagworte:	Cation Exchange Resins - adverse effects Colon - pathology Gastrointestinal diseases Gastrointestinal Diseases - chemically induced Health technology assessment Humans Hyperkalemia - drug therapy Ion exchange Necrosis - chemically induced Polystyrenes - adverse effects Potassium Prescription drugs Side effects Sodium
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Zusammenfassung:	ABSTRACTSodium polystyrene sulfonate (SPS), FDA-approved more than 60 years ago for treating hyperkalemia, is an ion exchange resin that works by exchanging sodium for potassium in the colon. Though widely used in clinical practice, SPS use is not supported by well-designed clinical trials. In 2009, the FDA issued a warning that SPS was associated with colonic necrosis and other serious gastrointestinal adverse reactions. This article reviews the pros and cons of SPS therapy.
ISSN:	1547-1896 0893-7400
DOI:	10.1097/01.JAA.0000458856.92020.1e