Swelling-induced K super(+) influx in cultured primary astrocytes

Swelling-induced K super(+) influx in cultured primary astrocytes

The effect of swelling of cultured primary astrocytes from rat brain in hypotonic medium on K super(+) influx has been studied. A decrease in osmolality from 310 to 180 mOsm increased the activity of sodium pump (ouabain-inhibited super(86)Rb super(+) influx) and Na super(+),K super(+),2Cl super(-)...

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Veröffentlicht in:Brain research 1994-01, Vol.655 (1-2), p.110-114
Hauptverfasser: Mongin, A A, Aksentsev, S L, Orlov, S N, Slepko, NG, Kozlova, M V, Maximov, G V, Konev, S V
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Sprache:eng
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Zusammenfassung:The effect of swelling of cultured primary astrocytes from rat brain in hypotonic medium on K super(+) influx has been studied. A decrease in osmolality from 310 to 180 mOsm increased the activity of sodium pump (ouabain-inhibited super(86)Rb super(+) influx) and Na super(+),K super(+),2Cl super(-) cotransport (ouabain-insentitive bumetanide-inhibited super(86)Rb super(+) influx) by 70 and 35%, respectively. It is suggested that activation of these transport systems makes it possible to retain a high potassium concentration in the cells under regulatory volume decrease.
ISSN:0006-8993