Factors contributing to the duration of untreated prodromal positive symptoms in individuals at ultra-high risk for psychosis

Abstract Individuals at ultra-high risk (UHR) for psychosis experience a considerable delay before appropriate clinical attention is provided. Therefore, we investigated the correlates of this delay by examining clinical, socio-demographic and neuropsychological contributors to the duration of untreated prodromal positive symptoms (DUPP) in them (n = 73). The slowly progressive mode of functional decline, defined as a small percentage drop in the Global Assessment of Functioning (GAF) score within the past year, and male gender, explained a considerable portion of the DUPP in the multivariate regression model (F = 9.269, p < 0.001). Slower functional decline may be correlated with delayed care during the UHR period.