Decreased cortical octopamine level in basal forebrain lesioned rats: A microdialysis study

Ibotenic acid-induced lesion of the basal forebrain resulted after 13 days in a 90% reduction of octopamine (OA) in the frontoparietal cortex of adult rats, whereas dihydroxyphenylacetic (DOPAC), homovanillic (HVA) and 5-hydroxyindolacetic (5-HIAA) acids were not modified as measured by microdialysi...

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Veröffentlicht in:	Neuroscience letters 1993-04, Vol.152 (1), p.45-47
Hauptverfasser:	Bendahan, Gladys, Boatell, M.Lluïsa, Mahy, Nicole
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism Animals Basal forebrain Biochemistry and metabolism Biological and medical sciences Central nervous system Choline O-Acetyltransferase - metabolism Chromatography, High Pressure Liquid Dialysis Frontal Lobe - metabolism Frontoparietal cortex Fundamental and applied biological sciences. Psychology Homovanillic Acid - metabolism Hydroxyindoleacetic Acid - metabolism Ibotenic acid Ibotenic Acid - toxicity Male Microchemistry Microdialysis Octopamine Octopamine - metabolism Parietal Lobe - metabolism Prosencephalon - drug effects Prosencephalon - metabolism Rats Rats, Sprague-Dawley Vertebrates: nervous system and sense organs
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Zusammenfassung:	Ibotenic acid-induced lesion of the basal forebrain resulted after 13 days in a 90% reduction of octopamine (OA) in the frontoparietal cortex of adult rats, whereas dihydroxyphenylacetic (DOPAC), homovanillic (HVA) and 5-hydroxyindolacetic (5-HIAA) acids were not modified as measured by microdialysis and high-performance liquid chromatography (HPLC) with electrochemical detection. At this time, cortical choline acetyltransferase (ChAT) activity was decreased by 34%. The results are discussed with respect to possible octopamine involvement in reduced age-associated performance in neurodegenerative processes.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(93)90479-5