Colloidal magnetic resonance contrast agents: effect of particle surface on biodistribution

Surface structure of dextran-coated superparamagnetic particles is studied as a biodistribution-defining factor. Colloidal particle and polymer molecule of the same size and similar outer structure are shown to possess similar biokinetics and biodistribution. A dense dextran layer on the particle su...

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Veröffentlicht in:	Journal of magnetism and magnetic materials 1993, Vol.122 (1), p.383-386
Hauptverfasser:	Papisov, M.I., Bogdanov, A., Schaffer, B., Nossiff, N., Shen, T., Weissleder, R., Brady, T.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Contrast media. Radiopharmaceuticals Medical sciences Pharmacology. Drug treatments
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Surface structure of dextran-coated superparamagnetic particles is studied as a biodistribution-defining factor. Colloidal particle and polymer molecule of the same size and similar outer structure are shown to possess similar biokinetics and biodistribution. A dense dextran layer on the particle surface is identified as a structure responsible for particle accumulation in the lymph nodes.
ISSN:	0304-8853
DOI:	10.1016/0304-8853(93)91115-N