PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer

Highlight • This study showed PTP1B was over-expression in NSCLC tissue and was associated with the overall survival of NSCLC patients. • In vitro studies demonstrated PTP1B promoted proliferation and metastasis of NSCLC cells by activating src and ERK1/2. • This study firstly explore the role of PT...

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Veröffentlicht in:	Cancer letters 2015-04, Vol.359 (2), p.218-225
Hauptverfasser:	Liu, Hongbing, Wu, Ying, Zhu, Suhua, Liang, Wenjun, Wang, Zhaofeng, Wang, Yunfen, Lv, Tangfeng, Yao, Yanwen, Yuan, Dongmei, Song, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - enzymology Adenocarcinoma - mortality Adenocarcinoma - secondary Animals Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - secondary Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - secondary Cell Line, Tumor Cell Proliferation Enzyme Activation Female Hematology, Oncology and Palliative Medicine Humans Kaplan-Meier Estimate Kinases Lung cancer Lung Neoplasms - enzymology Lung Neoplasms - mortality Lung Neoplasms - pathology Lymphatic Metastasis Male MAP Kinase Signaling System Medical research Metabolic disorders Metastasis Mice, SCID Middle Aged Neoplasm Transplantation Non-small cell lung cancer Proliferation Proportional Hazards Models Protein tyrosine phosphatase 1B Protein Tyrosine Phosphatase, Non-Receptor Type 1 - physiology Src src-Family Kinases - metabolism Studies
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Beschreibung
Zusammenfassung:	Highlight • This study showed PTP1B was over-expression in NSCLC tissue and was associated with the overall survival of NSCLC patients. • In vitro studies demonstrated PTP1B promoted proliferation and metastasis of NSCLC cells by activating src and ERK1/2. • This study firstly explore the role of PTP1B in NSCLC and provided a basis for the applications of PTP1B inhibitors in NSCLC.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2015.01.020