Hepatocyte nuclear factor 4 alpha promotes the invasion, metastasis and angiogenesis of neuroblastoma cells via targeting matrix metalloproteinase 14

Highlights • HNF4α is highly expressed and positively correlated with MMP-14 levels in neuroblastoma. • HNF4α is an independent factor for unfavorable outcome of neuroblastoma patients. • HNF4α facilitates the transcription of MMP-14 via binding with its promoter in neuroblastoma. • HNF4α promotes t...

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Veröffentlicht in:	Cancer letters 2015-04, Vol.359 (2), p.187-197
Hauptverfasser:	Xiang, Xuan, Zhao, Xiang, Qu, Hongxia, Li, Dan, Yang, Dehua, Pu, Jiarui, Mei, Hong, Zhao, Jihe, Huang, Kai, Zheng, Liduan, Tong, Qiangsong
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggressiveness Angiogenesis Animals Biotechnology Cell Line, Tumor Enzyme Induction Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genes Hematology, Oncology and Palliative Medicine Hepatocyte Nuclear Factor 4 - physiology Hepatocyte nuclear factor 4 alpha Histology Humans Kaplan-Meier Estimate Kinases Male Matrix metalloproteinase 14 Matrix Metalloproteinase 14 - genetics Matrix Metalloproteinase 14 - metabolism Metastasis Mice, Nude Neoplasm Invasiveness Neoplasm Transplantation Neovascularization, Pathologic - enzymology Neuroblastoma Neuroblastoma - blood supply Neuroblastoma - enzymology Neuroblastoma - mortality Neuroblastoma - pathology Patients Promoter Regions, Genetic Proportional Hazards Models Protein Binding Rodents Studies Transcription factors Transcription, Genetic Transcriptional Activation Transcriptional regulation Tumor Burden Tumorigenesis Tumors Vascular endothelial growth factor
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Zusammenfassung:	Highlights • HNF4α is highly expressed and positively correlated with MMP-14 levels in neuroblastoma. • HNF4α is an independent factor for unfavorable outcome of neuroblastoma patients. • HNF4α facilitates the transcription of MMP-14 via binding with its promoter in neuroblastoma. • HNF4α promotes the aggressiveness of neuroblastoma through up-regulating MMP-14. • HNF4α is a novel therapeutic target for neuroblastoma.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2015.01.008