The clinical significance of pvuii polymorphism estradiol receptor alpha gene to improve diagnosis of proliferative forms of benign breast dysplasia

The clinical significance of pvuii polymorphism estradiol receptor alpha gene to improve diagnosis of proliferative forms of benign breast dysplasia

The aim - to determine the role of single nucleotide polymorphism PvuII of the gene EsRα as an indicator of proliferative activity in benign breast dysplasia (BBD) and its effect on receptor status of breast tissue for expression EsRα. Defined genotype PvuII polymorphism EsRα, the expression level i...

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Veröffentlicht in:Georgian medical news 2015-01 (238), p.12-17
Hauptverfasser: Lukavenko, I M, Andryushchenko, V V, Garbuzova, V Iu, Yazykov, A V
Format: Artikel
Sprache:rus
Schlagworte:
Adolescent
Adult
Cell Proliferation - genetics
DNA-Cytosine Methylases - genetics
Estrogen Receptor alpha - genetics
Female
Fibrocystic Breast Disease - diagnosis
Fibrocystic Breast Disease - genetics
Fibrocystic Breast Disease - pathology
Fibrocystic Breast Disease - surgery
Gene Expression Regulation, Neoplastic
Humans
Middle Aged
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Zusammenfassung:The aim - to determine the role of single nucleotide polymorphism PvuII of the gene EsRα as an indicator of proliferative activity in benign breast dysplasia (BBD) and its effect on receptor status of breast tissue for expression EsRα. Defined genotype PvuII polymorphism EsRα, the expression level in remote EsRα among patients with BBD. For these patients, and morphological parameters samples are divided into groups and compared. It is shown that there is a connection between the PvuII-gene polymorphism EsRα with the degree of proliferation (χ2=43,142; p
ISSN:1512-0112