The link between testosterone and amygdala–orbitofrontal cortex connectivity in adolescent alcohol use

The link between testosterone and amygdala–orbitofrontal cortex connectivity in adolescent alcohol use

Highlights • We studied the link between alcohol use, testosterone and amygdala–OFC connectivity. • 173 participants between 12 and 25 years underwent a resting state fMRI scan. • Increased testosterone was linked to reduced amygdala–OFC connectivity. • Reduced amygdala–OFC connectivity was associat...

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Veröffentlicht in:Psychoneuroendocrinology 2015-03, Vol.53, p.117-126
Hauptverfasser: Peters, Sabine, Jolles, Dietsje J, Duijvenvoorde, Anna C.K. Van, Crone, Eveline A, Peper, Jiska S
Format: Artikel
Sprache:eng
Schlagworte:
Adolescence
Adolescent
Adult
Alcohol
Alcohol Drinking - metabolism
Alcohol Drinking - physiopathology
Amygdala
Amygdala - physiopathology
Brain - physiopathology
Child
Endocrinology & Metabolism
Female
Functional Neuroimaging
Humans
Magnetic Resonance Imaging
Male
Neural Pathways - physiopathology
Orbitofrontal cortex
Prefrontal Cortex - physiopathology
Psychiatry
Resting state
Risk-Taking
Testosterone
Testosterone - metabolism
Young Adult
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Beschreibung
Zusammenfassung:Highlights • We studied the link between alcohol use, testosterone and amygdala–OFC connectivity. • 173 participants between 12 and 25 years underwent a resting state fMRI scan. • Increased testosterone was linked to reduced amygdala–OFC connectivity. • Reduced amygdala–OFC connectivity was associated with decreased alcohol use. • Testosterone had an indirect effect on alcohol use through amygdala–OFC connectivity.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2015.01.004