Potential therapeutic targets in the process of nucleic acid recognition: opportunities and challenges
Highlights • Nucleic acid-sensing through PRRs plays a key role in modulating innate and adaptive immunity. • Microbial-origin PAMPs or DAMPs can be used as therapeutic antigens. • DNA helicases can by targeted by the arrest of replication and the breakage of DNA double strands. • The newly discover...
Gespeichert in:
| Veröffentlicht in: | Trends in pharmacological sciences (Regular ed.) 2015-01, Vol.36 (1), p.51-64 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 64 |
|---|---|
| container_issue | 1 |
| container_start_page | 51 |
| container_title | Trends in pharmacological sciences (Regular ed.) |
| container_volume | 36 |
| creator | He, Shaoheng Mao, Xiaoquan Sun, Hongzhi Shirakawa, Taro Zhang, Huiyun Wang, Xiangdong |
| description | Highlights • Nucleic acid-sensing through PRRs plays a key role in modulating innate and adaptive immunity. • Microbial-origin PAMPs or DAMPs can be used as therapeutic antigens. • DNA helicases can by targeted by the arrest of replication and the breakage of DNA double strands. • The newly discovered STING pathway may be a therapeutic target. |
| doi_str_mv | 10.1016/j.tips.2014.10.013 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1657316801</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165614714001904</els_id><sourcerecordid>1657316801</sourcerecordid><originalsourceid>FETCH-LOGICAL-c477t-db2ca4caa064084d8e89744df98509e1c4747c9877c66faeb5e25e3d653e1f5f3</originalsourceid><addsrcrecordid>eNp9kUGLFDEQhYMo7jj6BzxIjl56TDrpTreIsCy6KywoqOeQSapnM2aSNpUW9t-bZlYPHiSHkMd7j8pXhLzkbMcZ798cd8XPuGsZl1XYMS4ekQ0flGiEEt1jsqmmrum5VBfkGeKRMSZEy5-Si7aTaqxnQ6YvqUAs3gRa7iCbGZbiLS0mH6Ag9XGV6ZyTBUSaJhoXG6A6jPWOZrDpEH3xKb6laZ5TLsv6BKQmOmrvTAgQD4DPyZPJBIQXD_eWfP_44dvVTXP7-frT1eVtY6VSpXH71hppjWG9ZIN0AwyjktJN49CxEXh1SWXHQSnb95OBfQdtB8L1nQA-dZPYktfn3jrxzwWw6JNHCyGYCGlBXYEowfuhstqS9my1OSFmmPSc_cnke82ZXvnqo1756pXvqtVMDb166F_2J3B_I3-AVsO7swHqL395yBqth2jB-QqraJf8__vf_xO3wUdvTfgB94DHtORY-WmusdVMf103vC6YS8b4yKT4DdxVovc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1657316801</pqid></control><display><type>article</type><title>Potential therapeutic targets in the process of nucleic acid recognition: opportunities and challenges</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>He, Shaoheng ; Mao, Xiaoquan ; Sun, Hongzhi ; Shirakawa, Taro ; Zhang, Huiyun ; Wang, Xiangdong</creator><creatorcontrib>He, Shaoheng ; Mao, Xiaoquan ; Sun, Hongzhi ; Shirakawa, Taro ; Zhang, Huiyun ; Wang, Xiangdong</creatorcontrib><description>Highlights • Nucleic acid-sensing through PRRs plays a key role in modulating innate and adaptive immunity. • Microbial-origin PAMPs or DAMPs can be used as therapeutic antigens. • DNA helicases can by targeted by the arrest of replication and the breakage of DNA double strands. • The newly discovered STING pathway may be a therapeutic target.</description><identifier>ISSN: 0165-6147</identifier><identifier>EISSN: 1873-3735</identifier><identifier>DOI: 10.1016/j.tips.2014.10.013</identifier><identifier>PMID: 25479797</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Advanced Basic Science ; Animals ; DAMPs ; DNA and RNA sensing ; DNA Helicases - immunology ; DNA Helicases - metabolism ; Humans ; Immunity, Innate ; innate immunity ; Membrane Proteins - immunology ; Membrane Proteins - metabolism ; Nucleic Acids - immunology ; Nucleic Acids - metabolism ; Nucleotidyltransferases - immunology ; Nucleotidyltransferases - metabolism ; PAMPs ; pattern recognition receptor ; Receptors, Pattern Recognition - immunology ; Receptors, Pattern Recognition - metabolism ; RNA Helicases - immunology ; RNA Helicases - metabolism ; Th1 Cells - immunology ; Th2 Cells - immunology ; Toll-like receptor</subject><ispartof>Trends in pharmacological sciences (Regular ed.), 2015-01, Vol.36 (1), p.51-64</ispartof><rights>2014</rights><rights>Copyright © 2014. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-db2ca4caa064084d8e89744df98509e1c4747c9877c66faeb5e25e3d653e1f5f3</citedby><cites>FETCH-LOGICAL-c477t-db2ca4caa064084d8e89744df98509e1c4747c9877c66faeb5e25e3d653e1f5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tips.2014.10.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25479797$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Shaoheng</creatorcontrib><creatorcontrib>Mao, Xiaoquan</creatorcontrib><creatorcontrib>Sun, Hongzhi</creatorcontrib><creatorcontrib>Shirakawa, Taro</creatorcontrib><creatorcontrib>Zhang, Huiyun</creatorcontrib><creatorcontrib>Wang, Xiangdong</creatorcontrib><title>Potential therapeutic targets in the process of nucleic acid recognition: opportunities and challenges</title><title>Trends in pharmacological sciences (Regular ed.)</title><addtitle>Trends Pharmacol Sci</addtitle><description>Highlights • Nucleic acid-sensing through PRRs plays a key role in modulating innate and adaptive immunity. • Microbial-origin PAMPs or DAMPs can be used as therapeutic antigens. • DNA helicases can by targeted by the arrest of replication and the breakage of DNA double strands. • The newly discovered STING pathway may be a therapeutic target.</description><subject>Advanced Basic Science</subject><subject>Animals</subject><subject>DAMPs</subject><subject>DNA and RNA sensing</subject><subject>DNA Helicases - immunology</subject><subject>DNA Helicases - metabolism</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>innate immunity</subject><subject>Membrane Proteins - immunology</subject><subject>Membrane Proteins - metabolism</subject><subject>Nucleic Acids - immunology</subject><subject>Nucleic Acids - metabolism</subject><subject>Nucleotidyltransferases - immunology</subject><subject>Nucleotidyltransferases - metabolism</subject><subject>PAMPs</subject><subject>pattern recognition receptor</subject><subject>Receptors, Pattern Recognition - immunology</subject><subject>Receptors, Pattern Recognition - metabolism</subject><subject>RNA Helicases - immunology</subject><subject>RNA Helicases - metabolism</subject><subject>Th1 Cells - immunology</subject><subject>Th2 Cells - immunology</subject><subject>Toll-like receptor</subject><issn>0165-6147</issn><issn>1873-3735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGLFDEQhYMo7jj6BzxIjl56TDrpTreIsCy6KywoqOeQSapnM2aSNpUW9t-bZlYPHiSHkMd7j8pXhLzkbMcZ798cd8XPuGsZl1XYMS4ekQ0flGiEEt1jsqmmrum5VBfkGeKRMSZEy5-Si7aTaqxnQ6YvqUAs3gRa7iCbGZbiLS0mH6Ag9XGV6ZyTBUSaJhoXG6A6jPWOZrDpEH3xKb6laZ5TLsv6BKQmOmrvTAgQD4DPyZPJBIQXD_eWfP_44dvVTXP7-frT1eVtY6VSpXH71hppjWG9ZIN0AwyjktJN49CxEXh1SWXHQSnb95OBfQdtB8L1nQA-dZPYktfn3jrxzwWw6JNHCyGYCGlBXYEowfuhstqS9my1OSFmmPSc_cnke82ZXvnqo1756pXvqtVMDb166F_2J3B_I3-AVsO7swHqL395yBqth2jB-QqraJf8__vf_xO3wUdvTfgB94DHtORY-WmusdVMf103vC6YS8b4yKT4DdxVovc</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>He, Shaoheng</creator><creator>Mao, Xiaoquan</creator><creator>Sun, Hongzhi</creator><creator>Shirakawa, Taro</creator><creator>Zhang, Huiyun</creator><creator>Wang, Xiangdong</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>Potential therapeutic targets in the process of nucleic acid recognition: opportunities and challenges</title><author>He, Shaoheng ; Mao, Xiaoquan ; Sun, Hongzhi ; Shirakawa, Taro ; Zhang, Huiyun ; Wang, Xiangdong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-db2ca4caa064084d8e89744df98509e1c4747c9877c66faeb5e25e3d653e1f5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Advanced Basic Science</topic><topic>Animals</topic><topic>DAMPs</topic><topic>DNA and RNA sensing</topic><topic>DNA Helicases - immunology</topic><topic>DNA Helicases - metabolism</topic><topic>Humans</topic><topic>Immunity, Innate</topic><topic>innate immunity</topic><topic>Membrane Proteins - immunology</topic><topic>Membrane Proteins - metabolism</topic><topic>Nucleic Acids - immunology</topic><topic>Nucleic Acids - metabolism</topic><topic>Nucleotidyltransferases - immunology</topic><topic>Nucleotidyltransferases - metabolism</topic><topic>PAMPs</topic><topic>pattern recognition receptor</topic><topic>Receptors, Pattern Recognition - immunology</topic><topic>Receptors, Pattern Recognition - metabolism</topic><topic>RNA Helicases - immunology</topic><topic>RNA Helicases - metabolism</topic><topic>Th1 Cells - immunology</topic><topic>Th2 Cells - immunology</topic><topic>Toll-like receptor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Shaoheng</creatorcontrib><creatorcontrib>Mao, Xiaoquan</creatorcontrib><creatorcontrib>Sun, Hongzhi</creatorcontrib><creatorcontrib>Shirakawa, Taro</creatorcontrib><creatorcontrib>Zhang, Huiyun</creatorcontrib><creatorcontrib>Wang, Xiangdong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in pharmacological sciences (Regular ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Shaoheng</au><au>Mao, Xiaoquan</au><au>Sun, Hongzhi</au><au>Shirakawa, Taro</au><au>Zhang, Huiyun</au><au>Wang, Xiangdong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential therapeutic targets in the process of nucleic acid recognition: opportunities and challenges</atitle><jtitle>Trends in pharmacological sciences (Regular ed.)</jtitle><addtitle>Trends Pharmacol Sci</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>36</volume><issue>1</issue><spage>51</spage><epage>64</epage><pages>51-64</pages><issn>0165-6147</issn><eissn>1873-3735</eissn><abstract>Highlights • Nucleic acid-sensing through PRRs plays a key role in modulating innate and adaptive immunity. • Microbial-origin PAMPs or DAMPs can be used as therapeutic antigens. • DNA helicases can by targeted by the arrest of replication and the breakage of DNA double strands. • The newly discovered STING pathway may be a therapeutic target.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>25479797</pmid><doi>10.1016/j.tips.2014.10.013</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-6147 |
| ispartof | Trends in pharmacological sciences (Regular ed.), 2015-01, Vol.36 (1), p.51-64 |
| issn | 0165-6147 1873-3735 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1657316801 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Advanced Basic Science Animals DAMPs DNA and RNA sensing DNA Helicases - immunology DNA Helicases - metabolism Humans Immunity, Innate innate immunity Membrane Proteins - immunology Membrane Proteins - metabolism Nucleic Acids - immunology Nucleic Acids - metabolism Nucleotidyltransferases - immunology Nucleotidyltransferases - metabolism PAMPs pattern recognition receptor Receptors, Pattern Recognition - immunology Receptors, Pattern Recognition - metabolism RNA Helicases - immunology RNA Helicases - metabolism Th1 Cells - immunology Th2 Cells - immunology Toll-like receptor |
| title | Potential therapeutic targets in the process of nucleic acid recognition: opportunities and challenges |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T08%3A00%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Potential%20therapeutic%20targets%20in%20the%20process%20of%20nucleic%20acid%20recognition:%20opportunities%20and%20challenges&rft.jtitle=Trends%20in%20pharmacological%20sciences%20(Regular%20ed.)&rft.au=He,%20Shaoheng&rft.date=2015-01-01&rft.volume=36&rft.issue=1&rft.spage=51&rft.epage=64&rft.pages=51-64&rft.issn=0165-6147&rft.eissn=1873-3735&rft_id=info:doi/10.1016/j.tips.2014.10.013&rft_dat=%3Cproquest_cross%3E1657316801%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1657316801&rft_id=info:pmid/25479797&rft_els_id=S0165614714001904&rfr_iscdi=true |