Potential therapeutic targets in the process of nucleic acid recognition: opportunities and challenges

Highlights • Nucleic acid-sensing through PRRs plays a key role in modulating innate and adaptive immunity. • Microbial-origin PAMPs or DAMPs can be used as therapeutic antigens. • DNA helicases can by targeted by the arrest of replication and the breakage of DNA double strands. • The newly discover...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2015-01, Vol.36 (1), p.51-64
Hauptverfasser:	He, Shaoheng, Mao, Xiaoquan, Sun, Hongzhi, Shirakawa, Taro, Zhang, Huiyun, Wang, Xiangdong
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals DAMPs DNA and RNA sensing DNA Helicases - immunology DNA Helicases - metabolism Humans Immunity, Innate innate immunity Membrane Proteins - immunology Membrane Proteins - metabolism Nucleic Acids - immunology Nucleic Acids - metabolism Nucleotidyltransferases - immunology Nucleotidyltransferases - metabolism PAMPs pattern recognition receptor Receptors, Pattern Recognition - immunology Receptors, Pattern Recognition - metabolism RNA Helicases - immunology RNA Helicases - metabolism Th1 Cells - immunology Th2 Cells - immunology Toll-like receptor
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Zusammenfassung:	Highlights • Nucleic acid-sensing through PRRs plays a key role in modulating innate and adaptive immunity. • Microbial-origin PAMPs or DAMPs can be used as therapeutic antigens. • DNA helicases can by targeted by the arrest of replication and the breakage of DNA double strands. • The newly discovered STING pathway may be a therapeutic target.
ISSN:	0165-6147 1873-3735
DOI:	10.1016/j.tips.2014.10.013