Topological features of rugged fitness landscapes in sequence space

Topological features of rugged fitness landscapes in sequence space

Highlights • We review the concept of fitness landscapes in sequence space. • The genotype–phenotype relationship of a protein is complex and multidimensional. • Several experimental approaches are used to study fitness landscapes. • Fitness landscapes should be studied from a global perspective of...

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Veröffentlicht in:Trends in genetics 2015-01, Vol.31 (1), p.24-33
Hauptverfasser: Kondrashov, Dmitry A, Kondrashov, Fyodor A
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Animals
Epistasis, Genetic
Genetic Fitness
Humans
Medical Education
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Zusammenfassung:Highlights • We review the concept of fitness landscapes in sequence space. • The genotype–phenotype relationship of a protein is complex and multidimensional. • Several experimental approaches are used to study fitness landscapes. • Fitness landscapes should be studied from a global perspective of sequence space.
ISSN:0168-9525
DOI:10.1016/j.tig.2014.09.009