Escherichia coli O157:H7 requires intimin for enteropathogenicity in calves

Enterohemorrhagic Escherichia coli (EHEC) strains require intimin to induce attaching and effacing (A/E) lesions in newborn piglets. Infection of newborn calves with intimin-positive or intimin-negative EHEC O157:H7 demonstrated that intimin is needed for colonization. A/E lesions, and disease in ca...

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Veröffentlicht in:	Infection and Immunity 1998-09, Vol.66 (9), p.4560-4563
Hauptverfasser:	Dean-Nystrom, E.A, Bosworth, B.T, Moon, H.W, O'Brien, A.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial Animals bacteria Bacterial diseases Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - physiology Biological and medical sciences calf diseases Carrier Proteins Cattle Diarrhea - microbiology Diarrhea - pathology Escherichia coli Escherichia coli Infections - microbiology Escherichia coli Infections - pathology Escherichia coli O157 - metabolism Escherichia coli O157 - pathogenicity Escherichia coli Proteins Experimental bacterial diseases and models Infectious diseases Medical sciences Molecular and Cellular Pathogenesis pathogenicity Swine
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Beschreibung
Zusammenfassung:	Enterohemorrhagic Escherichia coli (EHEC) strains require intimin to induce attaching and effacing (A/E) lesions in newborn piglets. Infection of newborn calves with intimin-positive or intimin-negative EHEC O157:H7 demonstrated that intimin is needed for colonization. A/E lesions, and disease in cattle. These results suggest that experiments to determine if intimin-based vaccines reduce O157:H7 levels in cattle are warranted.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.66.9.4560-4563.1998