Disturbed phase relations in white matter hyperintensity based vascular dementia: An EEG directed connectivity study

Highlights • Directed functional connectivity shows a phase lead of the frontal regions to parieto-occipital regions in subjects without objective cognitive disturbance. • In white matter hyperintensity (WMH) based vascular dementia (VaD) this organisation of phase relationships is lost. • Undirecte...

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Veröffentlicht in:	Clinical neurophysiology 2015-03, Vol.126 (3), p.497-504
Hauptverfasser:	van Straaten, E.C.W, den Haan, J, de Waal, H, van der Flier, W.M, Barkhof, F, Prins, N.D, Stam, C.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Brain - pathology Brain - physiopathology Cognition Dementia, Vascular - pathology Dementia, Vascular - physiopathology Directed phase lag index EEG Electroencephalography Female Functional connectivity Humans Magnetic Resonance Imaging - methods Male Nerve Net - pathology Nerve Net - physiopathology Neural Pathways - pathology Neural Pathways - physiopathology Neurology Phase Lag Index Vascular dementia White Matter - pathology White Matter - physiopathology WMH
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Zusammenfassung:	Highlights • Directed functional connectivity shows a phase lead of the frontal regions to parieto-occipital regions in subjects without objective cognitive disturbance. • In white matter hyperintensity (WMH) based vascular dementia (VaD) this organisation of phase relationships is lost. • Undirected functional connectivity does not differ between control subjects and WMH-VaD patients.
ISSN:	1388-2457 1872-8952
DOI:	10.1016/j.clinph.2014.05.018