Similar outcome after transplantation of moderate macrovesicular steatotic and nonsteatotic livers when the cold ischemia time is kept very short
Summary Background Livers with moderate (30–60%) macrovesicular steatosis have been associated with poor outcome after transplantation. Aim of this study was to examine the outcome after transplantation of livers with moderate macrovesicular steatosis when the cold ischemia time (CIT) is kept very s...
Gespeichert in:
| Veröffentlicht in: | Transplant international 2015-03, Vol.28 (3), p.319-329 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 329 |
|---|---|
| container_issue | 3 |
| container_start_page | 319 |
| container_title | Transplant international |
| container_volume | 28 |
| creator | Westerkamp, Andrie C. Boer, Marieke T. Berg, Aad P. Gouw, Annette S. H. Porte, Robert J. |
| description | Summary
Background
Livers with moderate (30–60%) macrovesicular steatosis have been associated with poor outcome after transplantation. Aim of this study was to examine the outcome after transplantation of livers with moderate macrovesicular steatosis when the cold ischemia time (CIT) is kept very short.
Methods
Postoperative outcome of 19 recipients of a moderate steatotic liver were compared with a matched control group of 95 recipients of a nonsteatotic liver graft (1:5 ratio). We studied graft/patient survival rates, incidences of primary nonfunction, postoperative complications (classified according to the Clavien–Dindo classification), first‐week postoperative hepatic injury serum markers (AST/ALT), and liver function tests (PT time/bilirubin/lactate). In addition, we studied reversal of graft steatosis in follow‐up biopsies.
Results
Median CIT in livers with moderate steatosis and in controls was below 8 h in both groups. Although short‐ and long‐term patient/graft survival rates and results of liver function tests were similar, serum markers of hepatic injury and postoperative complications (especially grade IVa) were significantly higher in recipients of a moderate steatotic liver. Reversal of steatosis was seen in 9 of the 11 (82%) recipients with follow‐up liver biopsies.
Conclusion
Despite the association with severe postoperative complications, moderate macrovesicular steatotic livers can be used successfully for transplantation if the CIT is kept very short. |
| doi_str_mv | 10.1111/tri.12504 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1655520177</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1655520177</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3884-4ff9ae637e244109316f9b7cd608e01a934ef9d74ab617df55feba205c168e203</originalsourceid><addsrcrecordid>eNp1kctKBDEQRYMoOj4W_oAE3OiiNUknne6liC8QBB_rkElXmGh3Z0zSynyGf2x0fIBgNgXh1K26dRHapeSI5necgjuiTBC-giaUl6xgTMpVNCFNyQtSS76BNmN8JISwWpB1tMGE4EJyMkFvd653nQ7Yj8n4HrC2CQJOQQ9x3ukh6eT8gL3FvW8h6AS41yb4F4jOjB-NMYFOPjmD9dDiwQ-_H517gRDx6wwGnGaAje9a7KKZQe80Ti6PcxE_wTzhDC5wnPmQttGa1V2Ena-6hR7Oz-5PL4vrm4ur05PrwpR1zQtubaOhKiUwzml2SivbTKVpK1IDoTpbB9u0kutpRWVrhbAw1YwIQ6saGCm30MFSdx788wgxqT6vBl02DX6MilZCCEaolBnd_4M--jEMeTtFZVU1RNR1manDJZXPE2MAq-bB9TosFCXqIyeVc1KfOWV270txnPbQ_pDfwWTgeAm8ug4W_yup-9urpeQ7bRqfbw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1766905883</pqid></control><display><type>article</type><title>Similar outcome after transplantation of moderate macrovesicular steatotic and nonsteatotic livers when the cold ischemia time is kept very short</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library All Journals</source><creator>Westerkamp, Andrie C. ; Boer, Marieke T. ; Berg, Aad P. ; Gouw, Annette S. H. ; Porte, Robert J.</creator><creatorcontrib>Westerkamp, Andrie C. ; Boer, Marieke T. ; Berg, Aad P. ; Gouw, Annette S. H. ; Porte, Robert J.</creatorcontrib><description>Summary
Background
Livers with moderate (30–60%) macrovesicular steatosis have been associated with poor outcome after transplantation. Aim of this study was to examine the outcome after transplantation of livers with moderate macrovesicular steatosis when the cold ischemia time (CIT) is kept very short.
Methods
Postoperative outcome of 19 recipients of a moderate steatotic liver were compared with a matched control group of 95 recipients of a nonsteatotic liver graft (1:5 ratio). We studied graft/patient survival rates, incidences of primary nonfunction, postoperative complications (classified according to the Clavien–Dindo classification), first‐week postoperative hepatic injury serum markers (AST/ALT), and liver function tests (PT time/bilirubin/lactate). In addition, we studied reversal of graft steatosis in follow‐up biopsies.
Results
Median CIT in livers with moderate steatosis and in controls was below 8 h in both groups. Although short‐ and long‐term patient/graft survival rates and results of liver function tests were similar, serum markers of hepatic injury and postoperative complications (especially grade IVa) were significantly higher in recipients of a moderate steatotic liver. Reversal of steatosis was seen in 9 of the 11 (82%) recipients with follow‐up liver biopsies.
Conclusion
Despite the association with severe postoperative complications, moderate macrovesicular steatotic livers can be used successfully for transplantation if the CIT is kept very short.</description><identifier>ISSN: 0934-0874</identifier><identifier>EISSN: 1432-2277</identifier><identifier>DOI: 10.1111/tri.12504</identifier><identifier>PMID: 25545740</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Biopsy ; Cold Ischemia - methods ; cold ischemia time ; donor ; Fatty Liver - mortality ; Fatty Liver - pathology ; Fatty Liver - surgery ; Female ; Follow-Up Studies ; Graft Survival ; Humans ; Liver - pathology ; Liver Failure - mortality ; Liver Failure - pathology ; Liver Failure - surgery ; Liver Transplantation ; Male ; Middle Aged ; Netherlands - epidemiology ; Postoperative Period ; Retrospective Studies ; Severity of Illness Index ; steatosis ; survival ; Survival Rate - trends ; Time Factors ; Tissue Donors ; Young Adult</subject><ispartof>Transplant international, 2015-03, Vol.28 (3), p.319-329</ispartof><rights>2014 Steunstichting ESOT</rights><rights>2014 Steunstichting ESOT.</rights><rights>Copyright © 2015 Steunstichting ESOT. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3884-4ff9ae637e244109316f9b7cd608e01a934ef9d74ab617df55feba205c168e203</citedby><cites>FETCH-LOGICAL-c3884-4ff9ae637e244109316f9b7cd608e01a934ef9d74ab617df55feba205c168e203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftri.12504$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftri.12504$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25545740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Westerkamp, Andrie C.</creatorcontrib><creatorcontrib>Boer, Marieke T.</creatorcontrib><creatorcontrib>Berg, Aad P.</creatorcontrib><creatorcontrib>Gouw, Annette S. H.</creatorcontrib><creatorcontrib>Porte, Robert J.</creatorcontrib><title>Similar outcome after transplantation of moderate macrovesicular steatotic and nonsteatotic livers when the cold ischemia time is kept very short</title><title>Transplant international</title><addtitle>Transpl Int</addtitle><description>Summary
Background
Livers with moderate (30–60%) macrovesicular steatosis have been associated with poor outcome after transplantation. Aim of this study was to examine the outcome after transplantation of livers with moderate macrovesicular steatosis when the cold ischemia time (CIT) is kept very short.
Methods
Postoperative outcome of 19 recipients of a moderate steatotic liver were compared with a matched control group of 95 recipients of a nonsteatotic liver graft (1:5 ratio). We studied graft/patient survival rates, incidences of primary nonfunction, postoperative complications (classified according to the Clavien–Dindo classification), first‐week postoperative hepatic injury serum markers (AST/ALT), and liver function tests (PT time/bilirubin/lactate). In addition, we studied reversal of graft steatosis in follow‐up biopsies.
Results
Median CIT in livers with moderate steatosis and in controls was below 8 h in both groups. Although short‐ and long‐term patient/graft survival rates and results of liver function tests were similar, serum markers of hepatic injury and postoperative complications (especially grade IVa) were significantly higher in recipients of a moderate steatotic liver. Reversal of steatosis was seen in 9 of the 11 (82%) recipients with follow‐up liver biopsies.
Conclusion
Despite the association with severe postoperative complications, moderate macrovesicular steatotic livers can be used successfully for transplantation if the CIT is kept very short.</description><subject>Adult</subject><subject>Aged</subject><subject>Biopsy</subject><subject>Cold Ischemia - methods</subject><subject>cold ischemia time</subject><subject>donor</subject><subject>Fatty Liver - mortality</subject><subject>Fatty Liver - pathology</subject><subject>Fatty Liver - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Graft Survival</subject><subject>Humans</subject><subject>Liver - pathology</subject><subject>Liver Failure - mortality</subject><subject>Liver Failure - pathology</subject><subject>Liver Failure - surgery</subject><subject>Liver Transplantation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Netherlands - epidemiology</subject><subject>Postoperative Period</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>steatosis</subject><subject>survival</subject><subject>Survival Rate - trends</subject><subject>Time Factors</subject><subject>Tissue Donors</subject><subject>Young Adult</subject><issn>0934-0874</issn><issn>1432-2277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctKBDEQRYMoOj4W_oAE3OiiNUknne6liC8QBB_rkElXmGh3Z0zSynyGf2x0fIBgNgXh1K26dRHapeSI5necgjuiTBC-giaUl6xgTMpVNCFNyQtSS76BNmN8JISwWpB1tMGE4EJyMkFvd653nQ7Yj8n4HrC2CQJOQQ9x3ukh6eT8gL3FvW8h6AS41yb4F4jOjB-NMYFOPjmD9dDiwQ-_H517gRDx6wwGnGaAje9a7KKZQe80Ti6PcxE_wTzhDC5wnPmQttGa1V2Ena-6hR7Oz-5PL4vrm4ur05PrwpR1zQtubaOhKiUwzml2SivbTKVpK1IDoTpbB9u0kutpRWVrhbAw1YwIQ6saGCm30MFSdx788wgxqT6vBl02DX6MilZCCEaolBnd_4M--jEMeTtFZVU1RNR1manDJZXPE2MAq-bB9TosFCXqIyeVc1KfOWV270txnPbQ_pDfwWTgeAm8ug4W_yup-9urpeQ7bRqfbw</recordid><startdate>201503</startdate><enddate>201503</enddate><creator>Westerkamp, Andrie C.</creator><creator>Boer, Marieke T.</creator><creator>Berg, Aad P.</creator><creator>Gouw, Annette S. H.</creator><creator>Porte, Robert J.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201503</creationdate><title>Similar outcome after transplantation of moderate macrovesicular steatotic and nonsteatotic livers when the cold ischemia time is kept very short</title><author>Westerkamp, Andrie C. ; Boer, Marieke T. ; Berg, Aad P. ; Gouw, Annette S. H. ; Porte, Robert J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3884-4ff9ae637e244109316f9b7cd608e01a934ef9d74ab617df55feba205c168e203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biopsy</topic><topic>Cold Ischemia - methods</topic><topic>cold ischemia time</topic><topic>donor</topic><topic>Fatty Liver - mortality</topic><topic>Fatty Liver - pathology</topic><topic>Fatty Liver - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Graft Survival</topic><topic>Humans</topic><topic>Liver - pathology</topic><topic>Liver Failure - mortality</topic><topic>Liver Failure - pathology</topic><topic>Liver Failure - surgery</topic><topic>Liver Transplantation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Netherlands - epidemiology</topic><topic>Postoperative Period</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>steatosis</topic><topic>survival</topic><topic>Survival Rate - trends</topic><topic>Time Factors</topic><topic>Tissue Donors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Westerkamp, Andrie C.</creatorcontrib><creatorcontrib>Boer, Marieke T.</creatorcontrib><creatorcontrib>Berg, Aad P.</creatorcontrib><creatorcontrib>Gouw, Annette S. H.</creatorcontrib><creatorcontrib>Porte, Robert J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Westerkamp, Andrie C.</au><au>Boer, Marieke T.</au><au>Berg, Aad P.</au><au>Gouw, Annette S. H.</au><au>Porte, Robert J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Similar outcome after transplantation of moderate macrovesicular steatotic and nonsteatotic livers when the cold ischemia time is kept very short</atitle><jtitle>Transplant international</jtitle><addtitle>Transpl Int</addtitle><date>2015-03</date><risdate>2015</risdate><volume>28</volume><issue>3</issue><spage>319</spage><epage>329</epage><pages>319-329</pages><issn>0934-0874</issn><eissn>1432-2277</eissn><abstract>Summary
Background
Livers with moderate (30–60%) macrovesicular steatosis have been associated with poor outcome after transplantation. Aim of this study was to examine the outcome after transplantation of livers with moderate macrovesicular steatosis when the cold ischemia time (CIT) is kept very short.
Methods
Postoperative outcome of 19 recipients of a moderate steatotic liver were compared with a matched control group of 95 recipients of a nonsteatotic liver graft (1:5 ratio). We studied graft/patient survival rates, incidences of primary nonfunction, postoperative complications (classified according to the Clavien–Dindo classification), first‐week postoperative hepatic injury serum markers (AST/ALT), and liver function tests (PT time/bilirubin/lactate). In addition, we studied reversal of graft steatosis in follow‐up biopsies.
Results
Median CIT in livers with moderate steatosis and in controls was below 8 h in both groups. Although short‐ and long‐term patient/graft survival rates and results of liver function tests were similar, serum markers of hepatic injury and postoperative complications (especially grade IVa) were significantly higher in recipients of a moderate steatotic liver. Reversal of steatosis was seen in 9 of the 11 (82%) recipients with follow‐up liver biopsies.
Conclusion
Despite the association with severe postoperative complications, moderate macrovesicular steatotic livers can be used successfully for transplantation if the CIT is kept very short.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25545740</pmid><doi>10.1111/tri.12504</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0934-0874 |
| ispartof | Transplant international, 2015-03, Vol.28 (3), p.319-329 |
| issn | 0934-0874 1432-2277 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1655520177 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals |
| subjects | Adult Aged Biopsy Cold Ischemia - methods cold ischemia time donor Fatty Liver - mortality Fatty Liver - pathology Fatty Liver - surgery Female Follow-Up Studies Graft Survival Humans Liver - pathology Liver Failure - mortality Liver Failure - pathology Liver Failure - surgery Liver Transplantation Male Middle Aged Netherlands - epidemiology Postoperative Period Retrospective Studies Severity of Illness Index steatosis survival Survival Rate - trends Time Factors Tissue Donors Young Adult |
| title | Similar outcome after transplantation of moderate macrovesicular steatotic and nonsteatotic livers when the cold ischemia time is kept very short |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T20%3A24%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Similar%20outcome%20after%20transplantation%20of%20moderate%20macrovesicular%20steatotic%20and%20nonsteatotic%20livers%20when%20the%20cold%20ischemia%20time%20is%20kept%20very%20short&rft.jtitle=Transplant%20international&rft.au=Westerkamp,%20Andrie%20C.&rft.date=2015-03&rft.volume=28&rft.issue=3&rft.spage=319&rft.epage=329&rft.pages=319-329&rft.issn=0934-0874&rft.eissn=1432-2277&rft_id=info:doi/10.1111/tri.12504&rft_dat=%3Cproquest_cross%3E1655520177%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1766905883&rft_id=info:pmid/25545740&rfr_iscdi=true |