Detection of a cell-cycle inhibitor of Petunia hybrida protoplasts in an Arthrospira platensis extract

A chloroform crude extract of whole Arthrospira platensis cells, provisionally named A. platensis auto-inhibitor (APAI), was inhibitory to growth of human prostatic cells and was toxic to them at less than 25 μg/ml. With cultured protoplasts of Petunia hybrida, APAI was growth inhibitory, without cy...

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Veröffentlicht in:	Biotechnology letters 1998-06, Vol.20 (6), p.557-560
Hauptverfasser:	HOURS, M. C, LINARES, P. N, THI HAI PHAN, FILALI-MOUHIM, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthrospira platensis Biological and medical sciences Biology of microorganisms of confirmed or potential industrial interest Biotechnology Cell division Chloroform Cytotoxicity Fundamental and applied biological sciences. Psychology Miscellaneous Mission oriented research Petunia hybrida
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Zusammenfassung:	A chloroform crude extract of whole Arthrospira platensis cells, provisionally named A. platensis auto-inhibitor (APAI), was inhibitory to growth of human prostatic cells and was toxic to them at less than 25 μg/ml. With cultured protoplasts of Petunia hybrida, APAI was growth inhibitory, without cytotoxicity, at 500 μg/ml. Using flow cytometry, it was seen that APAI induced arrest of the plant cell division cycle at the G1 phase. © Rapid Science Ltd. 1998[PUBLICATION ABSTRACT]
ISSN:	0141-5492 1573-6776
DOI:	10.1023/A:1005345627274