All-encomPASsing regulation of β-cells: PAS domain proteins in β-cell dysfunction and diabetes

Highlights • Many Per-Arnt-Sim (PAS) proteins are present in β-cells and some are dysregulated in diabetes. • The Hif1α pathway regulates β-cell differentiation possibly through altering metabolism. • Arnt regulates insulin secretion through heterodimerization with multiple bHLH-PAS factors. • Pask...

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Veröffentlicht in:	Trends in endocrinology and metabolism 2015-01, Vol.26 (1), p.49-57
Hauptverfasser:	Sabatini, Paul V, Lynn, Francis C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arnt Aryl Hydrocarbon Receptor Nuclear Translocator - chemistry Aryl Hydrocarbon Receptor Nuclear Translocator - physiology Basic Helix-Loop-Helix Transcription Factors - chemistry Basic Helix-Loop-Helix Transcription Factors - physiology Bmal1 circadian Clock diabetes Diabetes Mellitus - genetics Diabetes Mellitus - metabolism Diabetes Mellitus - physiopathology Drosophila Proteins - chemistry Drosophila Proteins - physiology Endocrinology & Metabolism Hif1α Humans hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - chemistry Hypoxia-Inducible Factor 1, alpha Subunit - physiology insulin secretion Insulin-Secreting Cells - pathology Insulin-Secreting Cells - physiology Npas4 Nuclear Proteins - chemistry Nuclear Proteins - physiology PAS domain Pask Per Period Circadian Proteins - chemistry Period Circadian Proteins - physiology Protein Structure, Tertiary Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - physiology Sim Transcription Factors - chemistry Transcription Factors - physiology Vhl Von Hippel-Lindau Tumor Suppressor Protein - chemistry Von Hippel-Lindau Tumor Suppressor Protein - physiology β-cells
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Zusammenfassung:	Highlights • Many Per-Arnt-Sim (PAS) proteins are present in β-cells and some are dysregulated in diabetes. • The Hif1α pathway regulates β-cell differentiation possibly through altering metabolism. • Arnt regulates insulin secretion through heterodimerization with multiple bHLH-PAS factors. • Pask may play important roles in regulating both α- and β-cell function.
ISSN:	1043-2760 1879-3061
DOI:	10.1016/j.tem.2014.11.002