Folate, vitamin b12, homocysteine status and DNA damage in young Australian adults

We performed a cross-sectional study (n = 49 males, 57 females) and a randomized double-blind placebo-controlled dietary intervention study (n = 31/32 per group) to determine the effect of folate and vitamin B12 (B12) on DNA damage (micronucleus formation and DNA methylation) and plasma homocysteine...

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Veröffentlicht in:	Carcinogenesis (New York) 1998-07, Vol.19 (7), p.1163-1171
Hauptverfasser:	FENECH, M, AITKEN, C, RINALDI, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Chemical mutagenesis Chromosome Aberrations Cross-Sectional Studies Dietary Supplements DNA - drug effects DNA - metabolism DNA Damage DNA Methylation - drug effects Double-Blind Method Female Folic Acid - administration & dosage Folic Acid - blood Hematinics - administration & dosage Hematinics - blood Homocysteine - blood Humans Lymphocytes - drug effects Lymphocytes - metabolism Male Medical sciences Micronuclei, Chromosome-Defective - drug effects Placebos Toxicology Vitamin B 12 - administration & dosage Vitamin B 12 - blood
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Zusammenfassung:	We performed a cross-sectional study (n = 49 males, 57 females) and a randomized double-blind placebo-controlled dietary intervention study (n = 31/32 per group) to determine the effect of folate and vitamin B12 (B12) on DNA damage (micronucleus formation and DNA methylation) and plasma homocysteine (HC) in young Australian adults aged 18-32 years. None of the volunteers were folate deficient (i.e. red blood cell folate
ISSN:	0143-3334 1460-2180 1460-2180
DOI:	10.1093/carcin/19.7.1163