The allele T of rs10852936 confers risk for early-onset psoriasis

The allele T of rs10852936 confers risk for early-onset psoriasis

Highlights • The associations of rs10852936 with the phenotypic traits of psoriasis are studied in a large Chinese Han population. • The susceptibility effect of the risk allele T of rs10852936 declines with increasing age at psoriasis onset. • The allele T of rs10852936 confers risk for early-onset...

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Veröffentlicht in:Journal of dermatological science 2015-02, Vol.77 (2), p.129-131
Hauptverfasser: Li, Longnian, Wang, Wenjun, Cui, Hongzhou, Zheng, Xiaodong, Chen, Yan, Sheng, Yujun, Gao, Jinping, Shen, Changbing, Zeng, Ming, Zhang, Tangde, Sun, Liangdan, Zhang, Xuejun
Format: Artikel
Sprache:eng
Schlagworte:
Alleles
China - epidemiology
Dermatology
Egg Proteins - genetics
Female
Genome-Wide Association Study
Humans
Ikaros Transcription Factor - genetics
Male
Membrane Proteins - genetics
Phenotype
Polymorphism, Single Nucleotide - genetics
Psoriasis - epidemiology
Psoriasis - ethnology
Psoriasis - genetics
Risk Factors
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Zusammenfassung:Highlights • The associations of rs10852936 with the phenotypic traits of psoriasis are studied in a large Chinese Han population. • The susceptibility effect of the risk allele T of rs10852936 declines with increasing age at psoriasis onset. • The allele T of rs10852936 confers risk for early-onset psoriasis. • Single nucleotide polymorphisms in the region surrounding the IKZF3 - ZPBP2 locus influence psoriasis phenotype.
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2014.11.004